Nigeria will take on Ghana for a place in the 2022 FIFA World Cup.
This was confirmed on Saturday after the draw was conducted in Douala, Cameroon.
Egypt will take on Senegal, while Algeria play Cameroon.
Morocco have been paired with DR Congo and Mali clash with Tunisia.
These 10 countries were all winners of their groups in the second round of African World Cup qualifiers played between September and November.
They will now meet over two legs in March to determine which five teams will reach the finals.
The Confederation of African Football (CAF) will confirm the exact dates of the matches.
Egypt vs. Senegal
Cameroon vs. Algeria
Ghana vs. Nigeria
DR Congo vs. Morocco
Mali vs. Tunisia